App
Customer Support
USD
Find Bookings
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Cheap flight deals from Des Moines to Mcallen Starting at $181

Whether you’re going for a one-way or round-trip to Mcallen, we’ve got you covered! Check out these different flight options from Des Moines below.

  • One way
  • Round-trip
      • DSM17:29
        5h 32m
        1 stop
        MFE23:01
        Wed, Mar 19|Des Moines - Mcallen|American Airlines
        $181$585
        69% OFF
        69% OFF
        $585$181

        Choose American Airlines flights from Des Moines to Mcallen. The one-way connecting flight with American Airlines departs from Des Moines International Airport on Wed, Mar 19, arriving at McAllen-Miller International Airport. One-way Prices start from $181 including taxes and charges.

      • DSM14:57
        6h 49m
        1 stop
        MFE21:46
        Wed, Mar 19|Des Moines - Mcallen|United Airlines
        $184$585
        69% OFF
        69% OFF
        $585$184

        Choose United Airlines flights from Des Moines to Mcallen. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Wed, Mar 19, arriving at McAllen-Miller International Airport. One-way Prices start from $184 including taxes and charges.

      • DSM14:57
        6h 49m
        1 stop
        MFE21:46
        Tue, Mar 18|Des Moines - Mcallen|United Airlines
        $189$585
        68% OFF
        68% OFF
        $585$189

        Choose United Airlines flights from Des Moines to Mcallen. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Tue, Mar 18, arriving at McAllen-Miller International Airport. One-way Prices start from $189 including taxes and charges.

      • DSM05:00
        5h 2m
        1 stop
        MFE10:02
        Thu, Feb 27|Des Moines - Mcallen|American Airlines
        $222
        $222

        Choose American Airlines flights from Des Moines to Mcallen. The one-way connecting flight with American Airlines departs from Des Moines International Airport on Thu, Feb 27, arriving at McAllen-Miller International Airport. One-way Prices start from $222 including taxes and charges.

      • DSM15:01
        6h 20m
        1 stop
        MFE21:21
        Thu, Feb 27|Des Moines - Mcallen|United Airlines
        $231
        $231

        Choose United Airlines flights from Des Moines to Mcallen. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Thu, Feb 27, arriving at McAllen-Miller International Airport. One-way Prices start from $231 including taxes and charges.

      • DSM08:00
        5h 34m
        1 stop
        MFE13:34
        Tue, Mar 4|Des Moines - Mcallen|United Airlines
        $248
        $248

        Choose United Airlines flights from Des Moines to Mcallen. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Tue, Mar 4, arriving at McAllen-Miller International Airport. One-way Prices start from $248 including taxes and charges.

      • DSM15:01
        6h 20m
        1 stop
        MFE21:21
        Fri, Feb 28|Des Moines - Mcallen|United Airlines
        $336
        $336

        Choose United Airlines flights from Des Moines to Mcallen. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Fri, Feb 28, arriving at McAllen-Miller International Airport. One-way Prices start from $336 including taxes and charges.

      • DSM14:57
        6h 49m
        1 stop
        MFE21:46
        Fri, Mar 21|Des Moines - Mcallen|United Airlines
        $444
        $444

        Choose United Airlines flights from Des Moines to Mcallen. The one-way connecting flight with United Airlines departs from Des Moines International Airport on Fri, Mar 21, arriving at McAllen-Miller International Airport. One-way Prices start from $444 including taxes and charges.

      • DSM01:00 pm
        3h 5m
        Nonstop
        MFE02:00 pm
        Sat, Mar 1|Des Moines - Mcallen|American Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Des Moines to Mcallen flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. AA2326

    American Airlines

    05:17

    DSM

    2.2h

    07:27

    DFW

    SMTWTFS
    Search

  2. AA3050

    American Airlines

    08:21

    DFW

    1.7h

    10:02

    MFE

    SMTWTFS

  3. DL447

    Delta Air Lines

    05:33

    DSM

    2.4h

    08:54

    ATL

    SMTWTFS
    Search

  4. DL2104

    Delta Air Lines

    12:20

    ATL

    2.7h

    14:03

    AUS

    SMTWTFS

  5. DL4121

    Delta Air Lines

    15:00

    AUS

    1.4h

    16:25

    MFE

    SMTWTFS

  6. DL447

    Delta Air Lines

    05:33

    DSM

    2.4h

    08:54

    ATL

    SMTWTFS
    Search

  7. DL2886

    Delta Air Lines

    10:00

    ATL

    2.7h

    11:42

    AUS

    SMTWTFS

  8. DL4121

    Delta Air Lines

    15:00

    AUS

    1.4h

    16:25

    MFE

    SMTWTFS

  9. DL5414

    Delta Air Lines

    06:20

    DSM

    1.9h

    09:11

    DTW

    SMTWTFS
    Search

  10. DL1012

    Delta Air Lines

    12:15

    DTW

    3.3h

    14:30

    AUS

    SMTWTFS

  11. DL4121

    Delta Air Lines

    15:00

    AUS

    1.4h

    16:25

    MFE

    SMTWTFS

  12. DL5402

    Delta Air Lines

    06:53

    DSM

    1.4h

    08:15

    MSP

    SMTWTFS
    Search

  13. DL2709

    Delta Air Lines

    08:50

    MSP

    3.1h

    11:55

    AUS

    SMTWTFS

  14. DL4121

    Delta Air Lines

    15:00

    AUS

    1.4h

    16:25

    MFE

    SMTWTFS

  15. UA1982

    United Airlines

    08:00

    DSM

    2.6h

    10:36

    IAH

    SMTWTFS
    Search

  16. UA2161

    United Airlines

    14:50

    IAH

    1.4h

    16:16

    MFE

    SMTWT--

  17. UA1982

    United Airlines

    08:00

    DSM

    2.6h

    10:36

    IAH

    SMTWTFS
    Search

  18. UA4820

    United Airlines

    09:50

    IAH

    1.6h

    11:28

    MFE

    SMTWTFS

  19. UA6033

    United Airlines

    15:00

    DSM

    2.4h

    17:25

    IAH

    SMTWTFS
    Search

  20. UA600

    United Airlines

    19:55

    IAH

    1.4h

    21:21

    MFE

    SMTWT-S

  21. AA1710

    American Airlines

    17:39

    DSM

    2.2h

    19:52

    DFW

    SMTWTFS
    Search

  22. AA485

    American Airlines

    22:37

    DFW

    1.6h

    00:15

    MFE

    ---WTFS

  23. AA1710

    American Airlines

    17:39

    DSM

    2.2h

    19:52

    DFW

    SMTWTFS
    Search

  24. AA1084

    American Airlines

    21:10

    DFW

    1.8h

    22:55

    MFE

    SMTWTFS
Find more flights and airlines

When is the cheapest time to fly from Des Moines to Mcallen?

Explore the best time to buy affordable tickets to Mcallen with our price trend chart, which predicts how flight prices will change in the coming weeks from previous data.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When are flight tickets from Des Moines (DSM) to Mcallen (MFE) the cheapest?

    Airlines adjust prices for flights from Des Moines to Mcallen based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from Des Moines (DSM) to Mcallen (MFE) cost?

    According to Trip.com's data, the lowest price is around $409.

  • What is the transportation method from the main airport to downtown in Mcallen?

    • The distance from McAllen-Miller International Airport to downtown is about 3 km, by taxi about 20 minutes.

  • How many airports are there in Mcallen (MFE)?

    There are 1 airport(s) near Mcallen (MFE): McAllen-Miller International Airport.

How to find a cheap flight from Des Moines to Mcallen

If you leave it until the last minute and forget to check some of the key information when booking tickets, prices can often end up skyrocketing. Below, you can find our top tips for getting the best value flights – from changing dates to chasing deals, there are plenty ways to keep your next trip affordable.
1
Being flexible with your dates to get the cheapest Des Moines to Mcallen ticket.
Tap "Date" on flight search bar to scan through the calender for Des Moines to Mcallen airfare over next 6 months in 2025. If you would like to fly in next 3 months, it seems the cheapest date is on Wed, Mar 19 at $181 for one-way flights.
2
Compare cheap Des Moines to Mcallen flight deals from over hundreds of airlines.
Our extensive search allows you to compare prices from over 500 airlines to choose the cheapest flight tickets from Des Moines to Mcallen. The cheapest airline operating is American Airlines.
3
Set up a Price Alert
By setting up a Price Alert for your Des Moines to Mcallen route, you can easily track the price of your airline tickets from without manually checking every day.
4
Don't miss cheap Des Moines to Mcallen flight deals and promo codes.
You can always get the latest deals through Trip.com Deals and Promo Codes for cheap flights. If registering a free membership, you can receive more deals for your flights.
5
Book early or wait unitl the last minute.
It's always better to book early. Flight tickets tend to be the cheapest when they are first released, normally about a year before the departure date. So, check online as soon as the flights you want become available. If you miss the cheapest time, you can still find lower-priced tickets as the flight date approaches.
6
Search for flights on the go.
To get the best flight booking experience on the go, download Trip.com and search for cheap flight tickets from Des Moines to Mcallen to get exclusive deals for you.

Flight Info | Des Moines to Mcallen

Cheapest direct flight price$181
Off-season for travelJanuary
Peak season for travelDecember
Flight distance1,758.65 km
Popular airlineUnited Airlines

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.