App
Customer Support
AED
Find Bookings
Trip.com
>
Flights
>
Flights to Argentina
>
Flights to Santiago del Estero
>
Flights from La Serena to Santiago del Estero
Worldwide Coverage
Worldwide Coverage
Flights to over 5,000 cities
One-stop Service Guarantee
One-stop Service Guarantee
Price guaranteed upon confirmed payment, booking guaranteed once tickets issued
Secure Payment
Secure Payment
Convenient & reliable booking and payment system

Cheap flight deals from La Serena to Santiago del Estero Starting at AED 906

Discover our range of affordable one-way and round-trip flights from La Serena to Santiago del Estero and kick-start your next adventure today!

  • One way
  • Round-trip
      • LSC14:49
        18h 11m
        2 stops
        SDE09:00
        Thu, Feb 13|La Serena - Santiago del Estero|Sky Airline
        AED 906AED 1,526
        41% OFF
        41% OFF
        AED 1,526AED 906

        Choose Sky Airline flights from La Serena to Santiago del Estero. The one-way connecting flight with Sky Airline departs from La Florida Airport on Thu, Feb 13, arriving at Santiago Del Estero Airport. One-way Prices start from AED 906 including taxes and charges.

      • LSC14:20
        42h 40m
        2 stops
        SDE09:00
        Sat, Feb 15|La Serena - Santiago del Estero|Sky Airline
        AED 1,079AED 1,526
        28% OFF
        28% OFF
        AED 1,526AED 1,079

        Choose Sky Airline flights from La Serena to Santiago del Estero. The one-way connecting flight with Sky Airline departs from La Florida Airport on Sat, Feb 15, arriving at Santiago Del Estero Airport. One-way Prices start from AED 1,079 including taxes and charges.

      • LSC09:45
        23h 15m
        2 stops
        SDE09:00
        Thu, Feb 13|La Serena - Santiago del Estero|LATAM Airlines
        AED 1,093AED 1,526
        28% OFF
        28% OFF
        AED 1,526AED 1,093

        Choose LATAM Airlines flights from La Serena to Santiago del Estero. The one-way connecting flight with LATAM Airlines departs from La Florida Airport on Thu, Feb 13, arriving at Santiago Del Estero Airport. One-way Prices start from AED 1,093 including taxes and charges.

      • LSC14:26
        42h 34m
        2 stops
        SDE09:00
        Sat, Feb 15|La Serena - Santiago del Estero|LATAM Airlines
        AED 1,267
        AED 1,267

        Choose LATAM Airlines flights from La Serena to Santiago del Estero. The one-way connecting flight with LATAM Airlines departs from La Florida Airport on Sat, Feb 15, arriving at Santiago Del Estero Airport. One-way Prices start from AED 1,267 including taxes and charges.

      • LSC01:00 pm
        3h 5m
        Nonstop
        SDE02:00 pm
        Thu, Feb 20|La Serena - Santiago del Estero|Sky Airline
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

La Serena to Santiago del Estero flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. H2461

    Sky Airline

    15:53

    LSC

    1.0h

    16:54

    SCL

    S-T--F-
    Search

  2. AR1281

    Aerolineas Argentinas

    07:55

    SCL

    2.1h

    11:00

    AEP

    SMTW--S

  3. AR1460

    Aerolineas Argentinas

    07:10

    AEP

    1.8h

    09:00

    SDE

    SMTWTF-

  4. LA319

    LATAM Airlines

    20:40

    LSC

    0.9h

    21:36

    SCL

    ---WTF-
    Search

  5. AR1281

    Aerolineas Argentinas

    07:55

    SCL

    2.1h

    11:00

    AEP

    SMTW--S

  6. AR1460

    Aerolineas Argentinas

    07:10

    AEP

    1.8h

    09:00

    SDE

    SMTWTF-
Find more flights and airlines

When is the cheapest time to fly from La Serena to Santiago del Estero?

These price trend charts carefully monitor and predict how flight prices from La Serena to Santiago del Estero will change. Keep a close eye on them to understand when the best time to buy your tickets is.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When are flight tickets from La Serena (LSC) to Santiago del Estero (SDE) the cheapest?

    Airlines adjust prices for flights from La Serena to Santiago del Estero based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • What is the transportation method from the main airport to downtown in Santiago del Estero?

    • The distance from Santiago Del Estero Airport to downtown is about 4 km, by taxi about 20 minutes.

  • How many airports are there in Santiago del Estero (SDE)?

    There are 1 airport(s) near Santiago del Estero (SDE): Santiago Del Estero Airport.

How to find a cheap flight from La Serena to Santiago del Estero

If you don’t know some of the key things to look out for when buying flight tickets, prices can often end up sky high or, worse, sold out! We’ve carefully compiled our six most important steps to help ensure you’re getting the best deals when planning your next journey.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Info | La Serena to Santiago del Estero

Off-season for travelFebruary
Flight distance712.23 km
Popular airlineSky Airline

Contact Us

About

Other Services

Payment Methods
Our Partners
Copyright © 2025 Trip.com Travel Singapore Pte. Ltd. All rights reserved
Site Operator: Trip.com Travel Singapore Pte. Ltd.