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Flights from Medellin to Santiago del Estero
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Cheap flight deals from Medellin to Santiago del Estero Starting at €855

Discover our range of affordable one-way and round-trip flights from Medellin to Santiago del Estero and kick-start your next adventure today!

  • Round-trip
      • MDE15:33
        20h 32m
        2 stops
        SDE14:05
        Fri, Mar 14|Medellin - Santiago del Estero|Copa Airlines
        SDE17:00
        23h 10m
        2 stops
        MDE14:10
        Fri, Mar 21|Santiago del Estero - Medellin|Flybondi
        €855€2,648
        68% OFF
        68% OFF
        €2,648€855

        Choose Copa Airlines flights from Medellin to Santiago del Estero. The one-way connecting flight with Copa Airlines departs from Jose Marie Cordova Airport on Fri, Mar 14-Fri, Mar 21, arriving at Santiago Del Estero Airport. One-way Prices start from €855 including taxes and charges.

      • MDE13:13
        25h 32m
        2 stops
        SDE16:45
        Wed, Feb 19|Medellin - Santiago del Estero|JetSMART Airlines
        SDE13:00
        25h 13m
        2 stops
        MDE12:13
        Sun, Feb 23|Santiago del Estero - Medellin|Flybondi
        €894€2,648
        66% OFF
        66% OFF
        €2,648€894

        Choose JetSMART Airlines flights from Medellin to Santiago del Estero. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Wed, Feb 19-Sun, Feb 23, arriving at Santiago Del Estero Airport. One-way Prices start from €894 including taxes and charges.

      • MDE13:13
        25h 47m
        2 stops
        SDE17:00
        Mon, Mar 3|Medellin - Santiago del Estero|JetSMART Airlines
        SDE17:00
        45h 13m
        2 stops
        MDE12:13
        Fri, Mar 7|Santiago del Estero - Medellin|Flybondi
        €991€2,648
        63% OFF
        63% OFF
        €2,648€991

        Choose JetSMART Airlines flights from Medellin to Santiago del Estero. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Mon, Mar 3-Fri, Mar 7, arriving at Santiago Del Estero Airport. One-way Prices start from €991 including taxes and charges.

      • MDE17:00
        19h 5m
        1 stop
        SDE14:05
        Fri, Mar 14|Medellin - Santiago del Estero|avianca
        SDE17:00
        16h 10m
        1 stop
        MDE07:10
        Fri, Mar 21|Santiago del Estero - Medellin|Flybondi
        €1,054
        €1,054

        Choose avianca flights from Medellin to Santiago del Estero. The one-way connecting flight with avianca departs from Jose Marie Cordova Airport on Fri, Mar 14-Fri, Mar 21, arriving at Santiago Del Estero Airport. One-way Prices start from €1,054 including taxes and charges.

      • MDE10:09
        20h 51m
        2 stops
        SDE09:00
        Thu, Mar 13|Medellin - Santiago del Estero|JetSMART Airlines
        SDE09:30
        26h 5m
        2 stops
        MDE09:35
        Mon, Mar 17|Santiago del Estero - Medellin|Aerolineas Argentinas
        €1,107
        €1,107

        Choose JetSMART Airlines flights from Medellin to Santiago del Estero. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Thu, Mar 13-Mon, Mar 17, arriving at Santiago Del Estero Airport. One-way Prices start from €1,107 including taxes and charges.

      • MDE13:13
        29h 47m
        2 stops
        SDE21:00
        Sun, Mar 2|Medellin - Santiago del Estero|JetSMART Airlines
        SDE09:05
        29h 8m
        2 stops
        MDE12:13
        Sat, Mar 8|Santiago del Estero - Medellin|Aerolineas Argentinas
        €1,154
        €1,154

        Choose JetSMART Airlines flights from Medellin to Santiago del Estero. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Sun, Mar 2-Sat, Mar 8, arriving at Santiago Del Estero Airport. One-way Prices start from €1,154 including taxes and charges.

      • MDE17:00
        22h 10m
        1 stop
        SDE17:10
        Sun, Mar 2|Medellin - Santiago del Estero|avianca
        SDE14:15
        18h 55m
        1 stop
        MDE07:10
        Sat, Mar 8|Santiago del Estero - Medellin|Flybondi
        €1,163
        €1,163

        Choose avianca flights from Medellin to Santiago del Estero. The one-way connecting flight with avianca departs from Jose Marie Cordova Airport on Sun, Mar 2-Sat, Mar 8, arriving at Santiago Del Estero Airport. One-way Prices start from €1,163 including taxes and charges.

      • MDE13:03
        25h 27m
        2 stops
        SDE16:30
        Thu, Mar 13|Medellin - Santiago del Estero|avianca
        SDE16:10
        17h
        1 stop
        MDE07:10
        Mon, Mar 17|Santiago del Estero - Medellin|Flybondi
        €1,221
        €1,221

        Choose avianca flights from Medellin to Santiago del Estero. The one-way connecting flight with avianca departs from Jose Marie Cordova Airport on Thu, Mar 13-Mon, Mar 17, arriving at Santiago Del Estero Airport. One-way Prices start from €1,221 including taxes and charges.

      • MDE13:03
        25h 42m
        2 stops
        SDE16:45
        Wed, Feb 19|Medellin - Santiago del Estero|avianca
        SDE13:00
        20h 10m
        1 stop
        MDE07:10
        Sun, Feb 23|Santiago del Estero - Medellin|Flybondi
        €1,278
        €1,278

        Choose avianca flights from Medellin to Santiago del Estero. The one-way connecting flight with avianca departs from Jose Marie Cordova Airport on Wed, Feb 19-Sun, Feb 23, arriving at Santiago Del Estero Airport. One-way Prices start from €1,278 including taxes and charges.

      • MDE13:03
        25h 57m
        2 stops
        SDE17:00
        Mon, Mar 3|Medellin - Santiago del Estero|avianca
        SDE17:00
        16h 10m
        1 stop
        MDE07:10
        Fri, Mar 7|Santiago del Estero - Medellin|Flybondi
        €1,419
        €1,419

        Choose avianca flights from Medellin to Santiago del Estero. The one-way connecting flight with avianca departs from Jose Marie Cordova Airport on Mon, Mar 3-Fri, Mar 7, arriving at Santiago Del Estero Airport. One-way Prices start from €1,419 including taxes and charges.

      • MDE01:00 pm
        3h 5m
        Nonstop
        SDE02:00 pm
        Fri, Feb 21|Medellin - Santiago del Estero|Copa Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Medellin to Santiago del Estero flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. JA7755

    JetSMART Airlines

    10:14

    MDE

    3.0h

    13:15

    LIM

    -M-W-F-
    Search

  2. JA3841

    JetSMART Airlines

    22:05

    LIM

    4.3h

    04:20

    AEP

    SMTWTFS

  3. AR1460

    Aerolineas Argentinas

    07:10

    AEP

    1.8h

    09:00

    SDE

    SMTWTF-

  4. AV9329

    avianca

    12:37

    MDE

    0.9h

    13:33

    BOG

    SMTWTFS
    Search

  5. AV217

    avianca

    16:00

    BOG

    6.2h

    00:10

    EZE

    SMTWTFS

  6. FO5230

    Flybondi

    14:45

    AEP

    1.8h

    16:30

    SDE

    SMTWTFS

  7. JA821

    JetSMART Airlines

    13:13

    MDE

    7.1h

    21:21

    SCL

    S-T-T-S
    Search

  8. JA731

    JetSMART Airlines

    06:14

    SCL

    2.1h

    09:20

    AEP

    SMTWTFS

  9. AR1464

    Aerolineas Argentinas

    19:25

    AEP

    1.8h

    21:15

    SDE

    SM--T-S

  10. JA821

    JetSMART Airlines

    13:13

    MDE

    7.1h

    21:21

    SCL

    S-T-T-S
    Search

  11. JA731

    JetSMART Airlines

    06:14

    SCL

    2.1h

    09:20

    AEP

    SMTWTFS

  12. FO5230

    Flybondi

    14:45

    AEP

    1.8h

    16:30

    SDE

    SMTWTFS

  13. CM154

    Copa Airlines

    15:31

    MDE

    1.5h

    16:59

    PTY

    SMTWTFS
    Search

  14. CM454

    Copa Airlines

    19:04

    PTY

    7.1h

    04:09

    EZE

    SMTWTFS

  15. FO5230

    Flybondi

    14:45

    AEP

    1.8h

    16:30

    SDE

    SMTWTFS

  16. AV111

    avianca

    16:50

    MDE

    6.6h

    01:25

    EZE

    SMTWTFS
    Search

  17. FO5230

    Flybondi

    14:45

    AEP

    1.8h

    16:30

    SDE

    SMTWTFS

  18. LA2393

    LATAM Airlines

    18:20

    MDE

    3.1h

    21:25

    LIM

    SMTWTFS
    Search

  19. LA2396

    LATAM Airlines

    23:40

    LIM

    4.3h

    06:00

    EZE

    S-T-TFS

  20. FO5230

    Flybondi

    14:45

    AEP

    1.8h

    16:30

    SDE

    SMTWTFS
Find more flights and airlines

When is the cheapest time to fly from Medellin to Santiago del Estero?

Explore the best time to buy affordable tickets to Santiago del Estero with our price trend chart, which predicts how flight prices will change in the coming weeks from previous data.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When are flight tickets from Medellin (MDE) to Santiago del Estero (SDE) the cheapest?

    Airlines adjust prices for flights from Medellin to Santiago del Estero based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from Medellin (MDE) to Santiago del Estero (SDE) cost?

    According to Trip.com's data, the lowest price is around €715.

  • What is the transportation method from the main airport to downtown in Santiago del Estero?

    • The distance from Santiago Del Estero Airport to downtown is about 4 km, by taxi about 20 minutes.

  • How many airports are there in Santiago del Estero (SDE)?

    There are 1 airport(s) near Santiago del Estero (SDE): Santiago Del Estero Airport.

How to find a cheap flight from Medellin to Santiago del Estero

If you don’t know some of the key things to look out for when buying flight tickets, prices can often end up sky high or, worse, sold out! We’ve carefully compiled our six most important steps to help ensure you’re getting the best deals when planning your next journey.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com

Flight Info | Medellin to Santiago del Estero

Off-season for travelFebruary
Peak season for travelNovember
Flight distance3,969.73 km
Popular airlineavianca

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