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Cheap flight deals from Medellin to Santiago Starting at €146

For as little as €146, you can take your next adventure to Santiago without breaking the bank. Choose between one-way and return tickets from Medellin below.

  • One way
  • Round-trip
      • Cheapest nonstop
        MDE13:13
        6h 8m
        Nonstop
        SCL21:21
        Wed, Mar 5|Medellin - Santiago|JetSMART Airlines
        €146€235
        38% OFF
        38% OFF
        €235€146

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way direct flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Wed, Mar 5, arriving at Arturo Merino Benitez Airport. One-way Prices start from €146 including taxes and charges.

      • MDE15:12
        12h 5m
        1 stop
        SCL04:17
        Fri, May 9|Medellin - Santiago|JetSMART Airlines
        €150€235
        36% OFF
        36% OFF
        €235€150

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Fri, May 9, arriving at Arturo Merino Benitez Airport. One-way Prices start from €150 including taxes and charges.

      • MDE14:40
        13h 9m
        1 stop
        SCL05:49
        Mon, Mar 31|Medellin - Santiago|JetSMART Airlines
        €158€235
        33% OFF
        33% OFF
        €235€158

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Mon, Mar 31, arriving at Arturo Merino Benitez Airport. One-way Prices start from €158 including taxes and charges.

      • MDE07:28
        9h 29m
        1 stop
        SCL18:57
        Fri, Mar 14|Medellin - Santiago|JetSMART Airlines
        €159
        €159

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Fri, Mar 14, arriving at Arturo Merino Benitez Airport. One-way Prices start from €159 including taxes and charges.

      • MDE22:38
        18h 19m
        1 stop
        SCL18:57
        Mon, Mar 3|Medellin - Santiago|JetSMART Airlines
        €160
        €160

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Mon, Mar 3, arriving at Arturo Merino Benitez Airport. One-way Prices start from €160 including taxes and charges.

      • MDE21:15
        19h 47m
        1 stop
        SCL19:02
        Sat, Mar 8|Medellin - Santiago|JetSMART Airlines
        €166
        €166

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Sat, Mar 8, arriving at Arturo Merino Benitez Airport. One-way Prices start from €166 including taxes and charges.

      • MDE21:10
        19h 47m
        1 stop
        SCL18:57
        Sun, Mar 23|Medellin - Santiago|JetSMART Airlines
        €167
        €167

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Sun, Mar 23, arriving at Arturo Merino Benitez Airport. One-way Prices start from €167 including taxes and charges.

      • MDE06:00
        21h 17m
        1 stop
        SCL04:17
        Sun, May 4|Medellin - Santiago|JetSMART Airlines
        €167
        €167

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Sun, May 4, arriving at Arturo Merino Benitez Airport. One-way Prices start from €167 including taxes and charges.

      • MDE09:39
        17h 38m
        1 stop
        SCL04:17
        Wed, Apr 30|Medellin - Santiago|JetSMART Airlines
        €170
        €170

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Wed, Apr 30, arriving at Arturo Merino Benitez Airport. One-way Prices start from €170 including taxes and charges.

      • MDE09:38
        18h 11m
        1 stop
        SCL05:49
        Wed, Mar 26|Medellin - Santiago|JetSMART Airlines
        €171
        €171

        Choose JetSMART Airlines flights from Medellin to Santiago. The one-way connecting flight with JetSMART Airlines departs from Jose Marie Cordova Airport on Wed, Mar 26, arriving at Arturo Merino Benitez Airport. One-way Prices start from €171 including taxes and charges.

      • MDE01:00 pm
        3h 5m
        Nonstop
        SCL02:00 pm
        Fri, Feb 28|Medellin - Santiago|JetSMART Airlines
        Find More Flights
        Find More Flights

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Medellin to Santiago flight time & flight schedules

Flight info.
Departure
Arrival
Weekly Schedule

  1. JA5472

    JetSMART Airlines

    09:39

    MDE

    1.1h

    10:44

    CLO

    S-T----
    Search

  2. JA811

    JetSMART Airlines

    14:11

    CLO

    4.5h

    19:38

    ANF

    SM-W-FS

  3. H2297

    Sky Airline

    22:50

    ANF

    1.9h

    00:42

    SCL

    ---W---

  4. JA5474

    JetSMART Airlines

    09:39

    MDE

    1.1h

    10:44

    CLO

    -M--TFS
    Search

  5. JA801

    JetSMART Airlines

    21:57

    CLO

    5.7h

    05:39

    SCL

    SMTWTFS

  6. JA821

    JetSMART Airlines

    13:13

    MDE

    6.1h

    Nonstop

    21:21

    SCL

    S-T-T-S
    Search

  7. JA5476

    JetSMART Airlines

    14:10

    MDE

    1.1h

    15:15

    CLO

    S---T--
    Search

  8. JA801

    JetSMART Airlines

    21:57

    CLO

    5.7h

    05:39

    SCL

    SMTWTFS

  9. JA5117

    JetSMART Airlines

    16:13

    MDE

    0.9h

    17:09

    BOG

    SMT-TFS
    Search

  10. JA791

    JetSMART Airlines

    11:00

    BOG

    7.0h

    18:57

    SCL

    SMTWTFS

  11. AV9309

    avianca

    17:30

    MDE

    0.9h

    18:26

    BOG

    -M-W-F-
    Search

  12. AV097

    avianca

    21:40

    BOG

    5.6h

    04:15

    SCL

    SMTWTFS

  13. AV147

    avianca

    17:50

    MDE

    5.8h

    Nonstop

    01:40

    SCL

    S-T-T-S
    Search

  14. JA7751

    JetSMART Airlines

    18:09

    MDE

    3.0h

    21:10

    LIM

    SMTWTFS
    Search

  15. JA7737

    JetSMART Airlines

    04:20

    LIM

    3.5h

    09:51

    SCL

    ---W--S

  16. JA7751

    JetSMART Airlines

    18:09

    MDE

    3.0h

    21:10

    LIM

    SMTWTFS
    Search

  17. JA7731

    JetSMART Airlines

    23:30

    LIM

    3.5h

    04:01

    SCL

    SMTWTFS

  18. AV9375

    avianca

    18:57

    MDE

    1.0h

    19:55

    BOG

    SMTWTFS
    Search

  19. AV097

    avianca

    21:40

    BOG

    5.6h

    04:15

    SCL

    SMTWTFS
Find more flights and airlines

When is the cheapest time to fly from Medellin to Santiago?

Price trend charts are a great way of tracking how much your flights cost in the lead up to departure and can help you choose when to book your tickets. See how prices to Santiago from Medellin have changed and are set to move below.

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Find cheap airlines flights from Medellin to Santiago

Compare prices from various providers below to understand which option best suits your travel needs, before enjoying a comfortable journey with a trusted airline from Medellin to Santiago.
avianca logoavianca

Frequently Asked Questions

  • When are flight tickets from Medellin (MDE) to Santiago (SCL) the cheapest?

    Airlines adjust prices for flights from Medellin to Santiago based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.

  • How much do flights from Medellin (MDE) to Santiago (SCL) cost?

    According to Trip.com's data, the lowest price is around €306.

  • How long does it take to fly from Medellin (MDE) to Santiago (SCL)?

    It takes about 5 hours 59 minutes to fly from Medellin (MDE) to Santiago (SCL).

  • What is the transportation method from the main airport to downtown in Santiago?

    • The distance from Arturo Merino Benitez Airport to downtown is about 12 km, by taxi about 30 minutes.

  • What are the most popular airlines that fly from Medellin (MDE) to Santiago (SCL)?

    Airlines with flights from Medellin (MDE) to Santiago (SCL): JetSMART Airlines and avianca.

  • What's the most popular airline for non-stop flights from Medellin (MDE) to Santiago (SCL)?

    JetSMART Airlines operates 1 non-stop flights from Medellin (MDE) to Santiago (SCL).

  • How many airports are there in Santiago (SCL)?

    There are 1 airport(s) near Santiago (SCL): Arturo Merino Benitez Airport.

How to find a cheap flight from Medellin to Santiago

Understanding the common pitfalls when booking your flight tickets can help you save massively when it comes time to fly. We’ve listed our six essential steps to keep in mind when you’re booking flight tickets to help you find the best price.
1
Being flexible with your dates to get the cheapest Medellin to Santiago ticket.
Tap "Date" on flight search bar to scan through the calender for Medellin to Santiago airfare over next 6 months in 2025. If you would like to fly in next 3 months, it seems the cheapest date is on Wed, Mar 5 at €146 for one-way flights.
2
Compare cheap Medellin to Santiago flight deals from over hundreds of airlines.
Our extensive search allows you to compare prices from over 500 airlines to choose the cheapest flight tickets from Medellin to Santiago. The cheapest airline operating is JetSMART Airlines.
3
Set up a Price Alert
By setting up a Price Alert for your Medellin to Santiago route, you can easily track the price of your airline tickets from without manually checking every day.
4
Don't miss cheap Medellin to Santiago flight deals and promo codes.
You can always get the latest deals through Trip.com Deals and Promo Codes for cheap flights. If registering a free membership, you can receive more deals for your flights.
5
Book early or wait unitl the last minute.
It's always better to book early. Flight tickets tend to be the cheapest when they are first released, normally about a year before the departure date. So, check online as soon as the flights you want become available. If you miss the cheapest time, you can still find lower-priced tickets as the flight date approaches.
6
Search for flights on the go.
To get the best flight booking experience on the go, download Trip.com and search for cheap flight tickets from Medellin to Santiago to get exclusive deals for you.

Flight Info | Medellin to Santiago

Cheapest direct flight price€146
Cheapest return ticket price€239
Off-season for travelJanuary
Peak season for travelNovember
Flight distance4,435.22 km
Average flight time5 hours 59 minutes
Popular airlineavianca

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