Some top places to stay in Opelousas are near popular attractions like Opelousas Museum & Interpretive Center, St. Landry Catholic Church and Louisiana Orphan Train Museum/ Musée du train orphelin de Louisiane—so you can quickly get to top landmarks and amenities you need.

Begin your day with a tasty and satisfying breakfast! Holiday Inn Express & Suites OPELOUSAS by IHG (price from AED 481), Spark by Hilton Opelousas (price from AED 370) and Hampton Inn Opelousas (price from AED 437) provide the best breakfast to start your day.

Hampton Inn Opelousas (price from AED 437), Holiday Inn Express & Suites OPELOUSAS by IHG (price from AED 481) and Days Inn & Suites by Wyndham Opelousas (price from AED 280) include fitness facilities, so you can maintain your routine while traveling. Stay on track with your fitness goals while on the go!

Motel 6 Opelousas, La (price from AED 206), Holiday Inn Express & Suites OPELOUSAS by IHG (price from AED 481) and Days Inn & Suites by Wyndham Opelousas (price from AED 280) are excellent options for hotels with swimming pools. Book your stay to enjoy the pool and make your trip more enjoyable.

Some standout hotels in Opelousas close to Opelousas Museum & Interpretive Center include Hampton Inn Opelousas (price from AED 437), Studio 6 Suites Opelousas, LA (price from AED 292) and Holiday Inn Express & Suites OPELOUSAS by IHG (price from AED 481), all within easy walking or transit distance of Opelousas Museum & Interpretive Center, perfect for travelers wanting to explore the landmark and its surroundings.

Find the best hotel deals and promotions on Trip.com, available year-round for both first-time and loyal users. Please check the promotions page to see what promotions are available now on Trip.com.