Hotels in Santee, United States – Book at Best Prices 2026

Located in Santee, Quality Inn & Suites Santee I-95 is within a 15-minute walk of Santee Cooper Country Club and Santee State Park. This hotel is 24.9 mi (40.1 km) from Congaree National Park and 1.1 mi (1.7 km) from Santee National Golf Club. Take advantage of recreation opportunities such as a seasonal outdoor pool, or other amenities including complimentary wireless internet access and a fireplace in the lobby. Additional features at this hotel include a banquet hall and a vending machine. Grab a bite to eat at one of the hotel's many dining establishments, which include 7 restaurants and a coffee shop/cafe. Quench your thirst with your favorite drink at the bar/lounge. A complimentary full breakfast is served daily from 6:30 AM to 9:30 AM. Featured amenities include a business center, a 24-hour front desk, and multilingual staff. Free self parking is available onsite. Make yourself at home in one of the 106 air-conditioned rooms featuring LED televisions. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have bathtubs and hair dryers. Conveniences include desks and coffee/tea makers, as well as phones with free local calls.

Just off I‑95 in Santee, South Carolina, the Holiday Inn Santee offers a relaxing stay near the shores of Lake Marion, one of the largest lakes in the state. Surrounded by peaceful Lowcountry scenery, our location provides easy access while still feeling removed from the rush of everyday travel. Lake Marion is a major draw for anglers, famous for striped bass, crappie, bream, and some of the biggest catfish in the Southeast. Guests are also close to Santee State Park for boating and hiking, Edisto Memorial Gardens for seasonal blooms and butterflies, and several well‑known golf courses. Columbia and historic Charleston are both within driving distance for sightseeing, dining, and cultural attractions. After a day on the lake or at meetings, enjoy amenities designed for comfort and convenience, including free Wi‑Fi, a 24‑hour Business Center, an indoor heated pool, and an on‑site restaurant serving comforting favorites. Warm Southern hospitality and a convenient location make every stay easy, productive, and enjoyable.

Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 24.5 mi (39.5 km) from Congaree National Park and 1.2 mi (1.9 km) from Santee Town Hall. Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine. A complimentary buffet breakfast is included. Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite. Make yourself at home in one of the 61 guestrooms featuring microwaves and plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.

Experience the charm and warmth of Southern hospitality at Ramada by Wyndham Santee I-95. Conveniently located just off I-95 and US-1559 miles from Charleston International Airport -CHS our hotel welcomes you with free WiFi and parking as well as a bar room service and outdoor pool. Our non-smoking hotel is minutes from South Carolina State University golf courses for a weekend getaway fishing on Lake Marion or the nature trails in Santee State Park.