Hotels in Santee, United States – Book at Best Prices 2026

Located in Santee, Comfort Inn & Suites Santee is in the entertainment district, within a 5-minute drive of Santee Cooper Country Club and Santee National Golf Club. This hotel is 1.2 mi (1.9 km) from Santee Town Hall and 1.4 mi (2.2 km) from Santee State Park. Take advantage of recreation opportunities including a fitness center and a seasonal outdoor pool. Additional features at this hotel include complimentary wireless internet access, a fireplace in the lobby, and a vending machine. A complimentary buffet breakfast is included. Featured amenities include a business center, complimentary newspapers in the lobby, and a 24-hour front desk. Free self parking is available onsite. Stay in one of 61 guestrooms featuring plasma televisions. Your pillowtop bed comes with Frette Italian sheets. Complimentary wireless internet access keeps you connected, and satellite programming is available for your entertainment. Bathrooms have shower/tub combinations and hair dryers.

Red Roof Inn Santee offers a budget-friendly stay in the heart of "America's Value Golf Destination." Whether you're here for championship golf, lake recreation, or exploring the area, Red Roof Inn Santee provides dependable comfort and value in beautiful Santee, South Carolina. Red Roof Inn Santee is a welcoming and affordable choice for golf enthusiasts and families seeking relaxation near Lake Marion. With friendly service and thoughtful amenities, we make every stay simple and enjoyable. Guests can expect a pleasant stay with essentials, including free Wi-Fi, a free expanded cable package featuring HBO, a complimentary continental breakfast, and coffee in the lobby. Each room also features a microwave and mini-refrigerator for added convenience. We are proud to be a pet-friendly hotel, so your four-legged companion is always welcome. Our Santee, SC hotel is located near popular attractions such as Lake Marion Golf Course, Santee Cooper Country Club, Lake Marion, Santee State Park, the Santee National Wildlife Refuge, and the Santee Conference Center, all within easy reach.

Just off I‑95 in Santee, South Carolina, the Holiday Inn Santee offers a relaxing stay near the shores of Lake Marion, one of the largest lakes in the state. Surrounded by peaceful Lowcountry scenery, our location provides easy access while still feeling removed from the rush of everyday travel. Lake Marion is a major draw for anglers, famous for striped bass, crappie, bream, and some of the biggest catfish in the Southeast. Guests are also close to Santee State Park for boating and hiking, Edisto Memorial Gardens for seasonal blooms and butterflies, and several well‑known golf courses. Columbia and historic Charleston are both within driving distance for sightseeing, dining, and cultural attractions. After a day on the lake or at meetings, enjoy amenities designed for comfort and convenience, including free Wi‑Fi, a 24‑hour Business Center, an indoor heated pool, and an on‑site restaurant serving comforting favorites. Warm Southern hospitality and a convenient location make every stay easy, productive, and enjoyable.

Experience the charm and warmth of Southern hospitality at Ramada by Wyndham Santee I-95. Conveniently located just off I-95 and US-1559 miles from Charleston International Airport -CHS our hotel welcomes you with free WiFi and parking as well as a bar room service and outdoor pool. Our non-smoking hotel is minutes from South Carolina State University golf courses for a weekend getaway fishing on Lake Marion or the nature trails in Santee State Park.